Custom Synthesis

We offer a professional custom synthesis and process development service for quantities scale up from 1mg to 5 kg approx. Our laboratory is equipped to handle a wide variety of chemical reactions including: 1) Acetylation, 2) Wittig Reactions, 3) Oxidation, 4) Reduction, 5) Reactions at lower temperature e.g. Butyl Lithium reactions at -35(C.), 6) Friedel - Craft alkyation, 7) Friedel - Craft acylation, 8) Leukotriene and Prostaglandin Chemistry Asymmetric Synthesis.
Quality assurance and safety are an intrinsic part of our operations. In parallel with reaction chemistry we develop analytical methods to ensure the quality of feedstocks, in-process intermediates, and final products.
A comprehensive range of analytical facilities enables us to characterise product specification and performance. As with all our services, we put great emphasis on partnership and teamwork with our Client companies to generate a creative and problem solving environment.

Fine Chemicals

We specialise in the Chemistry of Pharmaceutical Intermediates, Prostaglandins Intermediates, Iophenoxic acid Derivatives and Metabolities in naturally derived drug products, and in assymmetric synthesis. In addition to synthesising specific molecules to customer requirements.

R&D / Contracts

We are confident of our ability to provide a professional R&D and Organic synthesis service across a broad spectrum of chemical reactions. In addition we are specialists in the Chemistry of Intermediates for naturally derived drug products, and Pharmaceutical Intermediates, Prostaglandins Intermediates and Metabolities, which hold promise as anti-cancer drugs and in the manufacture of Diagnostic Products. In addition we specialise in asymmetric synthesis and in the identification of impurities in drugs, by chemical synthesis or analysis.

Analytical Services

At PR euroCHEM good chemistry is supported by good analytical capability. In addition to supporting our in-house activities, we are interested in using our highly sophisticated instrumentation to provide an analytical and quality assurance service to the chemical and process industry. Our equipment:
Reactors 20L, 10L, 1L, 500ml with associated heating and cooling facilities
Heating to 250(C / Cooling to -35(C)
Scale up from 1 mg to 5kg. Scale up of multi-step reactions.
Analytical Instrumentation:
High Performance Liquid Chromatography
Model: Dionex Gynkotek autosampler, Gynkotek (UVD 340S) Detector, Chromeleon data system.
Gas Chromatography-Mass Spectra (Positive Chemical Ionisation)
Finnigan MD 1000 spec EI, PCI, NCI
FT-IR
Model: Mattson Satellite , range 6000-375 Wave number, DTGS detector
We have also access to NMR and another analytical instrumentation.

Identification of Impurities in Drug Formulations

The identification and quantification of trace impurities in drugs has increased in importance in line with higher potency and more targeted applications. We specialise in providing a prompt and accurate service to client companies which may require original or confirmatory data either by synthesis of the impurities or through application of analytical methodology.

We very much welcome the challenge of working with our clients in these specialised areas, and will be delighted for the opportunity of discussing your requirements with you...