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Our papers, patents and conferences

The following is a selection of some of the areas which PR euroCHEM has developed special expertise, and could facilitate the synthesis of molecules of interest to you, or provide the basis for joint R&D programmes. Please let us know if you find anything of interest to you, and allow us to bring our expertise to bear in developing a partnership with you.

1) Synthesis and Enzymology of Amino - Protected Methionine Derivatives As Inhibitors for Trypanothione Reductase from Trypansoma cruzi - Part 4, C.T. Yuen, J. Garforth, R-G. Jaouhari, J.H. McKie, A.H. Fairlamb and K.T. Douglas, Amino Acids, in Preparation????

2) Synthesis and Enzymology of Modified N - Benzyloxycarbonyl - L - Cycteinylglycyl - 3 - dimethylaminopropilamide Disulfides as Alternative Substrates for Trypanothione Reductase from Trypanosoma cruzi - Part 3, C.T. Yuen, J. Garforth, T. Besheya, R-G. Jaouhari, J.H. McKie, A.H. Fairlamb and K.T. Douglas, Amino Acids, 1999, 17, 175.

3) Phenothiazine Inhibitors of trypanothione reductase as Potential Antitrypanosomal and Antilesishmanial Drugs, C. Chan, H. Yin, J. Garforth, J.H. McKie, R-G. Jaouhari, P. Speers, K.T. Douglas P.J. Rock, V. Yardley, S.L. Croft and A.H. Fairlamb, J. Med. Chem., 1998, 41, 2, 148.

4) The Role of Sulfoacetaldehyde Sulfo-Lyase in the Mineralisation of Isethionate by an Environmental Acinetobacter, J.E. King, R-G. Jaouhari and J.P. Quinn, Microbiology, 1997, 143, 2339.

5) Novel Amino Acid/Peptide Derivatives and Phosphorus Analogues M.A. McKervey, B.J. Walker, P. Quinn and R. Jaouhari 4th International Meeting on Amino Acids, Vienna (Austria), 7-11th August 1995.

6) Synthesis of Mixed Disulfide Potential Alternative Substrates for Trypanothione and Glutathione Reductases, T. Besheya, R-G. Jaouhari, J.H. McKie, J. Garforth and K.T. Douglas, Amino Acids, 1995, 9 (1), 66.

7) Inhibitors of Trypanathione Reductase as Potential Antitrypanosomal Drugs, C. Chan, H. Yin, J. Garforth, J.H. McKie, R-G. Jaouhari, K.T. Douglas, A.H. Fairlamb and S.L. Croft, Biochem Soc Trans, (1995), 1995, 23, 5115.

8) Synthesis of Symmetric Disulfide as Potential Alternative Subtrates for Trypanothione Reductase and Glutathione Reductase : Part 1, R-G. Jaouhari, T. Besheya, J.H. McKie and K.T. Douglas, Amino Acids, (1995), 9(4), 327.

9) Synthesis of Asymmetric Disulfide as Potential Alternative Substrates for Trypanothione Reductanse and Glutathione Reductanse : Part 2, R-G. Jaouhari, T. Besheya, J.H. McKie and K.T. Douglas, Amino Acids, (1995), 9(4), 343

10) Synthesis of Mixed Disulphide Potential Alternative Substrates for Trypanothione and Glutathione Reductase, T. Besheya, R-G. Jaouhari, J.H. McKie, J. Garforth and K.T. Douglas, 4th International Meeting on Amino Acids, Vienna (Austria), 7-11th August 1995.

11) Rational Design of Peptide- Based Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal Drugs, J. Garforth, J.H. McKie, R-G. Jaouhari, T.J. Benson, A.H. Fairlamb and K.T. Douglas, Amino Acid, 1994, 6 (3), 295.

12) Use of Transferred Nuclear Overhauser Effect Spectroscopy to Study a Novel Inhibitor of Yease Glutathione Reductase, K.T. Embry, A. Mehta, S.J. Carrington, R-G. Jaouhari, J.H. McKie and K.T. Douglas, European J Biochemistry, 1994, 221, 793.

13) The First Protoberberine Alkaloid Analogue with in Vivo Animalarial Activity, D.L.C. McCall, J. Alexander, J. Barber, R-G. Jaouhari, A. Satoskar and R.D. Waigh, BioMed. Chem. Lett., 1994, 4, 1663.

14) A New Ruthenium Catalysed Reaction. Benzylation of Functional Aromatic Compounds, R-G. Jaouhari, Chemistry Lett., 1994, 10, 1781.

15) Improved Process for the Preparation of 2-Methyl-3-Trfluoromethylaniline: A Versatile Intermediate For Flunixin Preparation, R-G. Jaouhari and P. Quinn, Hterocycles, 1994, 38 (10), 2243.

16) Novel Appraches Toward Ninhydrin Analogs, R.R. Hark, D.B. Hauze, O. Petrovskaia, M.M. Joullie, R-G. Jaouhari and P. McComisky, Tetrahedron Lett, 1994, 35 (42), 7719.

17) The First Protoberberine Alkaloid Analogue with in Vivo Antimalarial Activity, D.L.C. McCall, R-G. Jaouhari and R.D. Waigh, Belgium Organic Synthesis Symposium, Namur (Belgium), July 1994, 109.

18) Bacterial Biotransformation studies of Bicyclic Arenes using Pseudomonas Putida, D.R. Boyd, M.R. Groocock, D.N. Sharma, J.F. Malone and R-G. Jaouhari, Belgium Organic Synthesis Symposium, Namur (Belgium), July 1994, 120.

19) 2-Alkylcyclobbutanones: References Markers for the Detection of Lipid-Containing Foodstuffs, D.R Boyd, P. Quinn, I. Brannigan and R-G. Jaouhari, Agriculture & Food Symposium, The Queen University of Belast, June, 1994.

20) Differential Recognition of Glutathione Reductase and Trypanothione Reductase, J. Garforth, T.J. Benson, J.H. McKie, R-G. Jaouhari, A. Borges, M. Cunningham, A.H. Fairlamb and K.T. Douglas, The Biochemical Society, 646th Meeting, University of Leeds (England), 1993 (March), 151.

21) Use of Transferred Nuclear Overhauser Spectroscopy to Study a Novel Inhibitor of Yease Glutathione Reductase, K.T. Embry, A. Mehta, S.J. Carrington, R-G. Jaouhari, J.H. McKie and K.T. Douglas, The Biochemical Society, 646th Meeting, Univesity of Leeds (England), 1993 (March), 150.

22) Rational Design of Peptide-Based Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal Drugs, J. Garfoth, J.H. McKie and R-G. Jaouhari, 3rd International Congress on Amino Acids, Peptides and Analogues, Vienna (Austria), Amino Acids, 1993, 5(1), 139.

23) Improved Efficiency and Selectivity in Peptide Synthesis : Use of Triethylsilane as a Carbocation Scavenger in Deprotection of t-Butyle Esters and T-Butoxycarbonyl - Protected Sites, A. Mehta, R-G. Jaouhari, T.J. Benson and K.T. Douglas, Tetrahedron Lett, 1992, 33, 5441.

24) Use of the Two Enantiomers of 7, 7-Dimethylbicyclo[3.2.0.]-hept-2-en-6-one to Form the Two Optically Active Sythons in a Convergent Synthesis of Leukotriene - B4, I.C. Coterill, R-G. Jaouhari, G. Dorman, S.M. Robers, F. Scheinmann and B.J. Wakefield, J Chem Soc, Perkin Trans 1, 1991, 2505.

25) Ruthenium catalysed additions to alkynes and their use in acylation réactions, C. Bruneau, M. Neveux, P. Dixneuf, S. Lécolier, Synlett Accounts and rapid communication in synthetic organic chemistry, 1991 N° 1 p755-763.

26) Chemoenzymetic, Enantiocomplementary, Total Asymetric Synthesis of Leukotrienes - B3 and B4, I.C. Coterill, G. Dorman, K. Faber, R-G. Jaouhari, S.M. Roberts, F. Scheinmann, J. Spreitz, A.G. Sutherland, J.A. Winders and B.J. Wakefield, J Chem Soc, Chem Comm, 1990, 1661.

27) Fluorine in Enzyme Chemistry, Part 2. Preparation of Difluoromethelyenephosphonate Analogues of Glycolytic phosphates. Approaching and Isosteric and Ioselectronic Phosphate Mimic, R.D. Chambers, R-G. Jaouhari and D. O'Hagan, Tetrahedron, 1989, 45, 5101.

28) General Study of the Benzylation of functionalized Aromatic Hydrocarbons Catalyzed by Ruthenium Complexes, R-G. Jaouhari, Revue Roumaine de Chimie, 1989, 8, 1733.

29) A New Ruthenium Catalysed Reaction: Benzylation of Aromatic Hetriocyclic Compounds, R-G. Jaouhari and P.H. Dixneuf, Inorg. Chem. Acta, 1988, 145(2), 17.

30) A Highly Selective Conversion of Bis [-2(Chloroethyl)] amine into the Corresponding Analogous Dialkylarsino, R-G. Jaouhari and P.G. Edwards, Bull Soc Chem Belges, 1988, 3, 237.

31) Carbonylation of tertiary alkyl halides, J.J. Brunet, P. Legars, Itkatchenko, S. Lecolier, Tet.Letters 29 N° 36 pp 4559-72, 1988.

32) Acétylčne in catalysis: a one step synthesis of vinyl carbamates with Ruthenium catalysts, C. Bruneau, P.H. Dixneuf, S. Lécolier, Journal of molecular catalysis, V 44 (1988) pp 175-178.

33) Carbon-Carbon Coupling and Alkylation of Furan and Thiophen, involving C-H Bond Activation, with Ruthenium Catalysts in Alcohol, R-G. Jaouhari, P. Guenot and P.H. Dixneuf, J.Chem.Soc., Chem Comm., 1986, 1255.

34) Palladium Catalysed One Pot Carbonylation of Heterocyclic Compounds into their Esters, in presence of Mercury salts, R-G. Jaouhari, P.H. Dixneuf and S. Lecolier, Tetrahedron Lett., 1986, 27, 6315.

35) Procčde de synthčse d'isocyanates et dérivés d'isocyanates, M.C. Bonnet, G. Dawkins, R-G. Jaouhari, I. Tkatchenko et S. Lecolier, French Patent: No 84 19969 (28/12/1984), European Patent: No 85 402511 (17/12/1985).

36) Déterminations cinétiques par microcalorimetrique différentielle - XVI - Décomposition du percarbonate de 0,0-t butyle et 0-isopropenyle en solution, R-G. Jaouhari, C. Filliatre et J.J. Villenave, Thermochim Acta 1983, 60, 341.

37) Déterminations cinétique par microalorimetrique differentielle -XVII- Décomposition du percarbonate de 0,0-t butyle et 0-vinyle en solution, R-G. Jaouhari, C. Filliatre et J.J. Villenave, Thermochim Acta, 1983, 60, 353.

38) Acétonylation radicalaire de la norbornanone-2 réaction avec la percarbonate isopropenyle, J.J. Villenave, C. Filliatre, R-G. Jaouhari et M. Baratchart, Bull Soc Chim Belge, 1983, 92, 167.

39) A convenient Synthesis of 1, 4-Diketones, R-G. Jaouhari, C. Filliatre, B Maillard et J.J. Villenave, Synth Comm, 1983, 13, 361.

40) Analysis en RMN 13C de mélanges d'isomčres: Acetonycyclanes et exacyclanes, M. Baratchart, C. Filliatre, R-G. Jaouhari, J.J. Villenave, B. Barre et M. Petraud, Analysis, 1983, 11, 136.

41) Dosage Spectrophotometrique de groupements carbonyles greffes sur des polymčres, J.J. Villenave, R-G. Jaouhari, C. Filliatre et M. Baratchart, Analysis, 1983, 11, 136.

42) Functionalisation de polymčres par action de percarbonates vinyliques, exemple: poly(exyethylenes), J.J. Villenave, C. Filliatre, R-G. Jaouhari et M. Baratchart, European Polymer J, 1983, 19, 575.

43) Décomposition de percarbonates vinyliques en solution: comportement particulier dans les alkylbenzenes et les alcenes, R-G. Jaouhari, C. Filliatre et J.J. Villenave, C R Acad Sc, 1983, 296(11), 891.

44) Réactions radicalaires de percarbonate de 0,0-t butyle et 0-isopropenyl: Acétonylations assistées par un co-amorceur, R-G. Jaouhari, C. Filliatre et J.J. Villenave, Canad J Chem, 1983, 61, 2295.

45) The mass Spectra of Acetonylation Cyclanones, R-G. Jaouhari, C. Filliatre, J.J. Villenave et G. Bourgeois, Org Mass Spectrum, 1983, 18(1), 149.

46) Décomposition hétérocylique de percarbonate de 0,0 methyl - l - phenyl -1 ethyl en solution, J. J. Villenave, B. Maillard, C. Filliatre et R-G. Jaouhari, Bull Soc Chim Belge, 1982, 91, 301.

47) A Free - Radical Acetonylation Method, R-G. Jaouhari, B. Maillard, C. Filliatre and J.J. Villenave, Synthesis, 1982, 760.

48) Synthčse d'aldehyde - fonctionnels par voie radicalaire, C. Filliatre, M. Baratchart, J.J. Villenave et R-G. Jaouhari, Tetrahedron Letters, 1982, 23, 3487.

49) Obtention d'aldehyde - fonctionnels au cours de la thermolyse du percarbonate de 0,0-t butyle et 0-vinyle en solution, C. Filliatre, J.J. Villenave, R-G. Jaouhari et M. Baratchart, Bull Soc Chem Fr, 1982, 11, 352.

50) Décomposition du percarbonate de 0,0-t butyle et 0-isopropenyle en solution dans les cyclanes, R-G. Jaouhari, B. Maillard, C. Filliatre et J.J. Villenave, Tetrahedron, 1982, 38, 3137.

51) Décomposition du percarbonate de 0,0-butyle et 0-isopropenyle en solution 11-partie : Acétonylation des cyclanones et oxacyclanes, R-G. Jaouhari, B. Maillard, C. Filliatre et J.J. Villenave, Tetrahedron, 1982, 39, 1559.

52) Acétonylation par voie radicalaire d'alcanes ramifiés : réactions de transfert de redicaux alkyles aux alcanes, J.J. Villenave, R-G. Jaouhari, C. Filliatre et M. Baratchart, C C Acad Sc, 1982, 292 (11), 977.

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